G Protein–Coupled Receptor-G–Proteinβγ–Subunit Signaling Mediates Renal Dysfunction and Fibrosis in Heart Failure

G Protein-Coupled Receptor-G-Protein βγ-Subunit Signaling Mediates Renal Dysfunction and Fibrosis in Heart Failure.

Development of CKD secondary to chronic heart failure (CHF), known as cardiorenal syndrome type 2 (CRS2), clinically associates with organ failure and reduced survival. Heart and kidney damage in CRS2 results predominantly from chronic stimulation of G protein-coupled receptors (GPCRs), including adrenergic and endothelin (ET) receptors, after elevated neurohormonal signaling of the sympathetic...

Renal Dysfunction in Acute Heart Failure

During treatment of acute heart failure (AHF), worsening renal function is often complicated and results in a complex clinical course. Furthermore, renal dysfunction is a strong independent predictor of long-term adverse outcomes in patients with AHF. Traditionally, the predominant cause of renal dysfunction has been attributed to impairment of cardiac output and relative underfilling of arteri...

Experimental mild renal insufficiency mediates early cardiac apoptosis, fibrosis, and diastolic dysfunction: a kidney-heart connection.

Impaired renal function with loss of nephron number in chronic renal disease (CKD) is associated with increased cardiovascular morbidity and mortality. However, the structural and functional cardiac response to early and mild reduction in renal mass is poorly defined. We hypothesized that mild renal impairment produced by unilateral nephrectomy (UNX) would result in early cardiac fibrosis and i...

A direct and functional interaction between the trimeric G protein Go and Rab5 in G proteincoupled receptor signaling

Autonomic Dysfunction in Heart Failure and Renal Disease

In the methods paper presented by Reulecke et al. (2012), autonomic function is examined in healthy preterm neonates, applying HRV to cardiorespiratory data using non-linear methods. Reference HRV data is currently only available for adults (Taskforce, 1996), but through a complex series of analyses, Reulecke et al. (2012) show that while the relationship between heart rate and respiration in p...